Laboratory of Keith T. Gagnon
at Southern Illinois University, Carbondale
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Repeat Expansion Disorders
CRISPR and Argonaute
Chromosomal RNA Biology
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Repeat Expansion RNA
Long Noncoding RNA
The New England Journal of Medicine published a commentary by Steven Dowdy covering our recent nucleic acid-based anti-CRISPR research!
Keith is notified that his NIH R03 proposal was selected for funding.
Chris Barkau's paper on novel anti-CRISPR small nucleic acid-based inhibitors (CRISPR SNuBs) is accepted for publication in Nucleic Acid Therapeutics and highlighted on the cover with Chris' custom cover art.
Keith and Dr. David Corey published guidelines for experiments with antisense oligos and small RNAs in Nucleic Acid Therapeutics.
Keith is notified that his NIH R15 proposal was selected for funding.
Keith is elected to a two-year term on the Oligonucleotide Therapeutics Society (OTS) Board of Directors.
Zachary Kartje graduated with his PhD and accepted a postdoc position with Jon Watts at the RNA Therapeutics Institute at the UMass Medical Center. Congratulations!
Mansi Parasrampuria joins the Gagnon lab to pursue a PhD through the Microbiology, Biochemistry and Molecular Biology graduate program. Welcome!
Adrian Pater joins the Gagnon lab to pursue a PhD through the Chemistry and Biochemistry graduate program. Welcome!
The Gagnon lab published a study with the Masad Damha lab on extensively chemically-modified CRISPR RNA in Nucleic Acids Research.
The Gagnon lab published a study on RNA-DNA chimeric CRISPR-Cas9 in Biochemistry.
Zach Kartje is awarded an SIU Dissertation Research Award (DRA).
Zach Kartje wins first place for his oral presentation at the SIU School of Medicine Gradaute Research Symposium held in Springfield, Illinois.
Kushal Rohilla wins an SIU Graduate and Professional Graduate Research (GPSC) Award.
Courtney Slavich is awarded a 1 year fellowship through the SIU Graduate School.
Undergraduate assistant and REACH Scholar Helen Mihm's research project on anti-venom aptamers is highlighted in local SIU news.
The Gagnon lab is awarded a small internal SIU SOM grant to characterize RNA on the chromatin with a new sequencing technique.
Graduate students Katy Ovington, Ramadevi Chilamkurthy, and Courtney Slavich join the Gagnon lab. Welcome!
Guide BioSci, Inc. is announced as runner up for the IDT Synthetic Biology challenge at the SynBioBeta meeting in San Francisco.
Congratulations to Kushal on publishing her review on RNA biology in repeat expansion disorders.
Keith starts Guide BioSci, Inc., a precision CRISPR engineering company for biotech and therapeutic applications.
Keith is awarded the OTS Young Investigator Award for 2017.
Dr. Maria Barton joined the Gagnon lab as a postdoc. Welcome Maria!
The Gagnon lab has been awarded an ALS research grant from the Judith and Jean Pape Adams Charitable Foundation to explore transcription and splicing of C9ORF72 as a potential therapeutic target for C9FTD/ALS.
Keith and Kushal attended the 4th RNA Metabolism in Neurological Disease meeting in San Diego where Kushal presented a poster.
Keith and Zach attended the 12th OTS meeting in Montreal. Congratulations to Zach for winning a poster award!
Congratulations to Eman, Zach, Kushal and Chris for acceptance of their paper on the Broccoli RNA aptamer to ACS Chemical Biology!
Eman Ageely successfully defended her M.S. thesis in Chemistry and Biochemistry. Congratulations!
Undergraduate assistants Gisela Cairo-Baza and Ariadna Cairo-Baza leave for graduate school, Indiana University and UC Merced, respectively, to pursue their Ph.D. degrees.
The Gagnon lab and Corey lab have published a crystal structure of the C9ORF72 antisense repeat RNA in Biochemistry.
The Gagnon lab has been awarded an ALSRP Therapeutic Idea Award through the DoD for developing c9FTD/ALS model cell lines to search for potential ALS small molecule therapeutics.
Keith attended the 11th OTS meeting in Leiden, The Netherlands and the 3rd RNA Metabolism in Neurological Disease meeting in Chicago, accompanied by Kushal, Zach and Eman.
Welcome to graduate students Chris and Aiysha, who officially joined the Gagnon lab.
The Gagnon lab has been awarded an ALS Association starter grant to develop and validate cell-based models of c9FTD/ALS.
Attended the 20th Annual RNA Society Meeting in Madison, Wisconsin. Kushal, Zach and Eman all presented posters on their research progress.
Undergraduates Gisela and Tony are awarded scholarships for 2015-2016 through the SIU Chemistry Department.
Congratulations to Gisela and Ariadna for winning the competitive 2015-2016 REACH Award for their team project proposal.
The Gagnon lab has been awarded a seed grant through the SIU School of Medicine for team development grant (TDG) proposal, in collaboration with Sean Moran's lab at SIU, to study the aggregation of repeat expansion RNA and dipeptides associated with c9FTD/ALS.
Official demo begins in Neckers 208 to prepare our newly renovated laboratory.
Finally got our Cary 400 (that we bought for a steal on Ebay) running... time to get some melt data!!
Graduate student Kushal Rohilla joins the Gagnon lab.
Submitted our first NIH grant, an R03 for probing and detection of repeat expansion RNAs.
Submitted a Team Development Grant (TDG) proposal to the SIU School of Medicine.
Presented our first original work on detection of repeat expansion sequences at OTS 2014.
Graduate students Eman Ageely and Zachary Kartje officially join the Gagnon lab.
Keith T. Gagnon begins his independent career as an assistant professor at SIU.
Interested students or prospective postdocs are encouraged to inquire about positions.